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New Streamlined Production Means Better Products


Corynex™ expression system makes production easier and more efficient.

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Ajinomoto's Corynex™ Expression System is simplified production — an easier, more efficient process that introduces fewer impurities. Dipeptides and oligopeptides, once produced via synthesis, can be manufactured via fermentation, improving purity, consistency and costs. Talk with Ajinomoto about producing recombinant proteins in large-scale batches and research-scale quantities.

Corynex Expression System Advantages

  • Breakthrough patented technology
  • Unique expression system overcomes traditional manufacturing difficulties
  • Proteins secreted in an active form
  • Promotes efficient production of large-scale batches with non-animal-origin raw materials


Expression Examples


Expression system Protein Accumulation Protein Extraction Refolding Purification process
E.coli Intra-Cell Additional Steps Required Additional Steps Required Complicated
Yeast Extra-Cell Not Required Additional Steps Required Complicated
CORYNEX Extra-Cell Not Required Not Required Simple


Corynex™ Examples


Protein Origin Accumulation
(mg/l)		 Activity
Transglutaminase (TG) Streptoverticillium 600 +
Serine-protease (SAM-P4) Streptomyces 15 +
Proryl-endopeptidase Streptoverticillium 150 +
Phytase Bacillus 150 +
Isomalto-dextranase Anthrobacter 180 +
Dextranase Anthrobacter 900 +
Epidermal Growth Factor Human 100 +
Serum albumin Human 0.1 Nt*1)
In Test-Tube Culture *1) not tested.

Ajinomoto is looking for partnering opportunities for the new Corynex™ expression system. Please contact CorynexSales@ajiusa.com to initiate a discussion.